Bradford W Daigneault,
Assistant Professor Of Reproductive Physiology
About Bradford W Daigneault
Dr. Daigneault is an Assistant Professor of Reproductive Physiology in the Department of Animal Sciences and a Courtesy Faculty member of Large Animal and Clinical Sciences. He conducts basic and applied research using large animal models to address environmental stressors that affect male fertility and subsequent embryo development. Common laboratory techniques include sperm function assays, in vitro fertilization, CRISPR delivery for gene editing in oocytes, and various genomic and epigenomic strategies. His laboratory is also conducting research to understand embryo origins of placental formation.
Equine reproduction is a separate focus of investigation with projects to advance the commercialization of equine in vitro fertilization, immunocontraception in feral horses and methods to improve shipment of cooled stallion sperm for artificial insemination.
Teaching Profile
Research Profile
Environmental influences on post-ejaculatory sperm function through embryo development
The laboratory specializes in utilizing large animal models to address emerging and existing reasons for infertility in animals and humans. We primarily use bovine gametes and embryos to address idiopathic subfertility that also serve as models for human embryo development. Existing projects in the laboratory equally span male and female reproductive biology with a concentric focus on basic functions that drive early embryo development for applied and translational agriculture and biomedical sciences. Assisted reproductive technologies are a large component of research (IVF, ET, AI, vitrification) spanning multiple species (bovine, equine, ovine, porcine). Complementary techniques include the use of CRISPR/Cas technologies (zygotic injection, electroporation) for gene editing to identify genomic requirements of early embryo development and pregnancy recognition including paternal contributions to blastocyst formation. In complement, the laboratory models gamete and embryo environmental interactions with a focus on environmental stressors that alter sperm function and embryo development both structurally and at the genome/epigenomic levels. We also optimize and design semen extenders for multiple purposes in different species for commercial and research applications.
0000-0002-8329-4221
- Biology of reproduction (embryo development, maintenance of pregnancy, and genetic control of reproduction)
- Fertility Preservation
Publications
Grants
Education
Contact Details
- Business:
- (352) 273-2021
- Business:
- b.daigneault@ufl.edu
- Business Mailing:
-
PO Box 110910
GAINESVILLE FL 32611