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UF Health University of Florida
Large Animal Clinical Sciences College of Veterinary Medicine
Bradford W Daigneault

Bradford W Daigneault

Assistant Professor of Reproductive Physiology

Department: AG-ANIMAL SCIENCES
Business Phone: (352) 273-2021
Business Email: b.daigneault@ufl.edu

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About Bradford W Daigneault

Dr. Daigneault is an Assistant Professor of Reproductive Physiology in the Department of Animal Sciences and a Courtesy Faculty member of Large Animal and Clinical Sciences. He conducts basic and applied research using large animal models to address environmental stressors that affect male fertility and subsequent embryo development. Common laboratory techniques include sperm function assays, in vitro fertilization, CRISPR delivery for gene editing in oocytes, and various genomic and epigenomic strategies. His laboratory is also conducting research to understand embryo origins of placental formation.

Equine reproduction is a separate focus of investigation with projects to advance the commercialization of equine in vitro fertilization, immunocontraception in feral horses and methods to improve shipment of cooled stallion sperm for artificial insemination.

Related Links:
Equine Faculty

Teaching Profile

Courses Taught

  1. ANS4915 – Honors Thesis Research in Animal Sciences

    College of Agricultural and Life Sciences

  2. ANS6312C – Applied Livestock Reproduction

    College of Agricultural and Life Sciences

  3. ANS3319C – Reproductive Physiology and Endocrinology in Domestic Animals

    College of Agricultural and Life Sciences

  4. ANS6751 – Physiology of Reproduction

    College of Agricultural and Life Sciences

  5. ANS6932 – Special Topics in Animal Science

    College of Agricultural and Life Sciences

  6. ANS4932 – Special Topics in Animal Sciences

    College of Agricultural and Life Sciences

  7. ANS4320C – Applied Livestock Reproduction

    College of Agricultural and Life Sciences

  8. ANS6905 – Problems in Animal Science

    College of Agricultural and Life Sciences

  9. ANS6940 – Supervised Teaching

    College of Agricultural and Life Sciences

  10. GMS6491 – Journal Club in Physiology

    College of Medicine

Research Profile

Environmental influences on post-ejaculatory sperm function through embryo development

The laboratory specializes in utilizing large animal models to address emerging and existing reasons for infertility in animals and humans. We primarily use bovine gametes and embryos to address idiopathic subfertility that also serve as models for human embryo development. Existing projects in the laboratory equally span male and female reproductive biology with a concentric focus on basic functions that drive early embryo development for applied and translational agriculture and biomedical sciences. Assisted reproductive technologies are a large component of research (IVF, ET, AI, vitrification) spanning multiple species (bovine, equine, ovine, porcine). Complementary techniques include the use of CRISPR/Cas technologies (zygotic injection, electroporation) for gene editing to identify genomic requirements of early embryo development and pregnancy recognition including paternal contributions to blastocyst formation. In complement, the laboratory models gamete and embryo environmental interactions with a focus on environmental stressors that alter sperm function and embryo development both structurally and at the genome/epigenomic levels. We also optimize and design semen extenders for multiple purposes in different species for commercial and research applications.

Areas of Interest

  • Biology of reproduction (embryo development, maintenance of pregnancy, and genetic control of reproduction)
  • Fertility Preservation

Publications

Academic Articles

Grants

  1. Association of Glucose Metabolism and Insulin Sensitivity with Feed Efficiency and Production Traits in Beef Bulls

    Active

    Role:
    Co-Project Director/Principal Investigator
    Funding:
    FL CATTLE ENHANCEMENT BOARD via FL DEPT OF AG AND CONSUMER SER

  2. A CRISPR Approach To Determining PPARG Regulation Of Fatty Acid Availability That Influences Embryo Origins Of Conceptus Formation In Cattle

    Active

    Role:
    Principal Investigator
    Funding:
    US DEPT OF AG NATL INST OF FOOD AND AG

  3. Association between residual feed intake and fertility-related measures in young bulls

    Role:
    Co-Project Director/Principal Investigator
    Funding:
    FL CATTLE ENHANCEMENT BOARD via FL DEPT OF AG AND CONSUMER SER

  4. Finding new sperm traits that more accurately estimate bull fertility for semen analyses

    Role:
    Principal Investigator
    Funding:
    FL CATTLE ENHANCEMENT BOARD via FL DEPT OF AG AND CONSUMER SER

  5. PhD Scholarship Program, US-Pakistan Knowledge Corridor (Phase I) – Muhammad Sohail Siddique

    Active

    Role:
    Principal Investigator
    Funding:
    UF FOUNDATION via HIGHER EDUCATION COMMISSION PAKISTAN

  6. Reproductive Biotechnology Concentration at University of Florida

    Role:
    Co-Project Director/Principal Investigator
    Funding:
    US DEPT OF AG NATL INST OF FOOD AND AG

Education

  1. Postdoc Scholar – USDA, NIH T32 Trainee

    Michigan State University

  2. PhD Student – Animal Sciences

    University of Illinois

  3. MS Student – Biomedical Sciences – Equine Reproduction

    Colorado State University

  4. Undergraduate Student

    Texas A&M University

Contact Details

Phones:
Business:
(352) 273-2021
Emails:
Business:
b.daigneault@ufl.edu
Addresses:
Business Mailing:
PO Box 110910
 GAINESVILLE FL 32611